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**Labthink HGA-02 Headspace Gas Analyzer for Vial Gas Content Analysis**
[Chinese Packaging Network News] To ensure the quality of medicines and other products packaged in vials during storage, companies often fill vials with a specific amount of nitrogen. This process helps reduce oxygen and water vapor levels, thereby extending the shelf life of the product. The actual gas content inside the vial—particularly oxygen, carbon dioxide, and nitrogen—is a critical factor affecting product stability and is an essential parameter for pharmaceutical manufacturers to monitor. In this article, we introduce the use of Labthink’s HGA-02 headspace gas analyzer to measure the concentration of these gases in vials, providing a reliable method and testing equipment for accurate gas content analysis.
**1. What is a Vial?**
Vials are controlled or molded injection bottles, typically made from soda-lime glass or borosilicate glass. They come in various colors, such as transparent or brown, and are commonly used for packaging injections, vaccines, freeze-dried drugs, and biological agents. During the packaging process, a high concentration of nitrogen is often introduced into the vials to minimize oxygen and moisture levels, which can degrade the drug over time. However, due to limitations in the filling process or packaging tightness, the gas composition within the vial is not static. Monitoring these gas components is crucial for maintaining product quality, making it essential to implement effective gas content monitoring strategies.
**2. Testing Standards**
Currently, there are no standardized testing protocols for analyzing headspace gas components or residual oxygen in packaging containers. This lack of standardization highlights the importance of developing reliable analytical methods to ensure product safety and consistency.
**3. Test Sample**
The test involved finished packaging of powder injection vials produced by a company.
**4. Testing Equipment**
The HGA-02 headspace gas analyzer, developed by Jinan Languang Electromechanical Technology Co., Ltd., was used to analyze the gas composition in the vial samples.
**Figure 2: HGA-02 Headspace Gas Analyzer**
**4.1 Testing Principle**
The HGA-02 is equipped with high-precision oxygen and carbon dioxide sensors. During testing, the gas inside the vial is collected using a gas collection device and then analyzed. Oxygen and carbon dioxide levels are measured directly, while nitrogen content is calculated by subtracting the sum of oxygen and carbon dioxide from 100%.
**4.2 Application Scope**
This device is suitable for rapid and accurate detection of oxygen, carbon dioxide, and other gases in various packaging types, including sealed bags, packaging containers, and vials. It is widely used in pharmaceutical, food, and beverage industries.
**4.3 Equipment Specifications**
- Measurable gases: Oxygen (0–100%), Carbon Dioxide (0–100%)
- Oxygen accuracy: ±0.3% (for 0–2%), ±0.5% (for 2–100%)
- Carbon dioxide accuracy: ±0.5%
- High-precision sensors and professional design ensure accurate results
- Built-in micro-printer for instant result printing
- User-friendly interface with LCD display and bilingual (Chinese/English) support
**5. Testing Procedure**
1. Set test parameters on the PVC panel.
2. Place the vial sample into the gas collection device and carefully remove the stopper.
3. Insert the needle into the gas collection unit.
4. Start the test by clicking the test button. The device draws and analyzes the gas, displaying the oxygen and carbon dioxide content after the test completes.
**6. Test Results**
Three groups of vial samples were tested. The results are summarized in Table 1:
**Table 1: Gas Content Results of Three Groups of Samples**
| Gas Content (%) | Sample 1 | Sample 2 | Sample 3 |
|------------------|----------|----------|----------|
| Oxygen | 1.91 | 2.03 | 1.98 |
| Carbon Dioxide | 0.12 | 0.11 | 0.14 |
| Nitrogen | 97.97 | 97.86 | 97.88 |
**7. Conclusion**
The gas content in vials significantly impacts the quality of the packaged product. Using the HGA-02 headspace gas analyzer, this study demonstrated accurate and repeatable measurements of oxygen, carbon dioxide, and nitrogen levels. These results provide valuable insights for improving nitrogen filling processes and enhancing vial sealing performance. Labthink continues to offer advanced testing solutions to customers globally, covering a wide range of industries, including pharmaceuticals, food, and packaging. For more information about our equipment and services, please visit our website or contact us directly. The more you know, the more you trust! We look forward to strengthening technical cooperation with industry partners.