In a world once filled with science fiction dreams, the idea of replacing an organ with a new one is becoming increasingly real. At the recent 3D printing and clinical medicine application summit forum, experts revealed that China has made significant progress in using biomaterials to "print" functional livers capable of being used for transplants. These bioengineered livers are expected to enter clinical trials within the next 3 to 5 years. One example of how 3D printing is transforming medical treatment involves a man who accidentally broke his wrist while scrolling through WeChat. Doctors used 3D printing technology to create a detailed model of his hand, which helped accurately locate the injury and guide the surgery. This kind of precise preoperative planning and intraoperative assistance is now a common application of 3D printing in healthcare. Professor Wang Xiaohong from Tsinghua University's Department of Mechanical Engineering and the National Organ Manufacturing Center shared insights on her lab’s breakthroughs. Previously, 3D-printed livers lacked biological activity, but recent advancements have led to the development of livers that closely mimic human functions, including blood vessels and nerves. By combining natural and synthetic polymers, researchers have created livers that show great promise for future transplantation. The technology is currently in animal testing, and she is optimistic about its potential to enter clinical trials in the near future. She also mentioned ongoing research into printing other organs like the heart and breast, which could significantly extend human life if successful. However, not all experts are as optimistic. Professor Zhang Xiaoping from Union Hospital’s Urology Department emphasized the complexity of the human body. Even with advanced 3D printing, creating fully functional organs remains a challenge. He noted that replicating complex organs like the heart or lungs requires extensive research and time before they can be successfully implemented. Xu Mingen, vice chairman of the China 3D Printing Technology Industry Alliance, believes it will take at least 15 years before complex human organs can be fully printed and used in clinical settings. Currently, in cities like Beijing and Shanghai, simpler tissues such as bones and teeth are already being 3D-printed to match patients' anatomical needs. In the past, implants were often adjusted on the spot, but now more personalized solutions are becoming available. Some hospitals in Wuhan have started experimenting with this approach. As 3D printing continues to evolve, its impact on medicine is undeniable. From accurate surgical planning to the creation of functional organs, this technology is paving the way for a future where organ shortages and surgical precision could become things of the past. While challenges remain, the journey toward a world where “printed” organs save lives is well underway. (Editor)

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