Tumor stem cells are considered to be in a "dormant state" that hardly proliferates in the body. Although chemotherapy drugs can suppress the proliferation of tumor cells, it is difficult to play a role in stem cells. Even if the tumor seems to have disappeared after chemotherapy, as long as a small amount of stem cells remain, it will lead to cancer recurrence and metastasis. A research team led by Professor Kyushu Nakayama of Kyushu University in Japan found that a protein called "Fbxw7" in tumor stem cells can suppress cell division. They genetically manipulated experimental mice with chronic myeloid leukemia to prevent tumor stem cells from making this protein. After that, the researchers let the experimental rats take the chemotherapy drug "Gleevec", and no longer gave it after 35 days. The study found that under normal circumstances, experimental mice with leukemia will have a recurrence rate of 90% after 60 days, while the relapse rate of experimental mice that cannot produce "Fbxw7" protein is only about 20%. The research team judged that the cancer stem cells had died. Keiichi Nakayama said: "If you develop a drug that blocks the action of this protein and use it with chemotherapy drugs at the same time, you can hope to cure the cancer."
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