On September 20th, the latest academic achievement in the journal Science brought good news: the pharmaceutical company Sanofi and the National Institutes of Health (NIH) jointly developed a "three-in-one" specific antibody that can be expected to defend. Monkeys are protected from SHIV infection and are superior to single natural antibodies! With regard to AIDS, scientists have never stopped "the road to conquest." The vaccine is considered to be the only way to end the spread of this deadly virus. However, the variability and latent nature of HIV has made AIDS vaccine research and development challenging. On September 20th, the latest academic achievement in the journal Science brought good news: the pharmaceutical company Sanofi and the National Institutes of Health (NIH) jointly developed a "three-in-one" specific antibody that can be expected to defend. Monkeys are protected from SHIV infection and are superior to single natural antibodies! "three in one" antibody This highly anticipated antibody binds to three different sites on the HIV surface, protecting against more HIV. Anthony S. Fauci, director of the NIH National Institute of Allergy and Infectious Diseases (NIAID), said: "Collecting antibodies that bind to different sites of the HIV virus is expected to overcome the virus's mutations and achieve good control." Dr. John R. Mascola, Director of the NIAID Vaccine Research Center (VRC), Gary J. Nabel, Chief Scientific Officer and Senior Vice President of Sanofi, led the team to complete the study. They tested dozens of bispecific and trispecific antibodies in the lab to find the best combination to create multiple "triple" antibodies. With Sanofi's patented technology, they can combine monoclonal antibodies with trispecific antibodies. In the end, they found the most effective "recipe" - a unique combination of three widely neutralizing antibodies: VRC01, PGDM1400 and 10E8v4, which combined a novel antibody. Schematic diagram of "three-in-one" antibody structure: blue, green and purple parts can identify different viral sites (Source: NIAID) Animal experiments confirm the effectiveness of trispecific antibodies Scientists at the Vaccine Research Center used monkeys and two SHIV strains as models to test for trispecific antibodies. One of the SHIVs was sensitive to the neutralization reaction induced by VRC01 and the trispecific antibody, but did not respond to the neutralization of PGDM1400. Another type of SHIV is sensitive to the neutralization of PGDM1400 and trispecific antibodies, but is not sensitive to the neutralization of VRC01. They selected 24 monkeys and divided them into 3 groups to inoculate VRC01, PGDM1400 and trispecific antibodies. Five days later, the researchers gave the monkeys a SHIV virus. The results showed that 5 monkeys vaccinated with PGDM1400 antibody and 6 monkeys vaccinated with VRC01 antibody were eventually infected with SHIV. However, monkeys vaccinated with trispecific antibodies were not infected with HIV. This suggests that this three-in-one antibody is effective in preventing HIV. Sanofi is producing trispecific antibodies for clinical phase I, and trials are expected to be conducted by the end of 2018 to test antibody safety and pharmacokinetics. In addition, the NIAID-funded AIDS clinical trial team is planning to conduct a separate clinical Phase I trial. Mascola said: "The cooperation between NIAID and Sanofi has a milestone. We will try to push this specific antibody from the laboratory to the clinic." In addition to AIDS, this 3-in-1 antibody can also be used in other infectious diseases. In the prevention and treatment of autoimmune diseases and AIDS. Shanghai Chuangsai Technology has excellent performance, interleukin cytokines, fetal bovine serum, electrophoresis equipment scientific instruments, raw material drug standards, chemical reagents, cell culture consumables, Shanghai Chuangsai, mass products special promotions, welcome to inquire! Hospital Nursing Bed,Homecare Nursing Bed,Nursing Care Patient Bed,Semi Electric Homecare Bed Jiangmen Jia Mei Medical Products Co.,Ltd. , https://www.jmmedicalequipment.com
